Depression medication ratings
How patients on Drugs.com rate each drug, against how many of them reviewed it. The most-reviewed antidepressants cluster mid-scale, while the highest ratings mostly come from older or off-label drugs with far fewer reviews.
Rating vs number of reviews
Each dot is one drug, with its generic and brand-name listings combined. Hover or tap a dot for details. Tap a group to hide or show it.
Ratings by drug class
Each dot is a drug and the bar is the class average, weighted by review count, so heavily reviewed drugs count for more. Uses every rated drug in the selected view; only the group and class filters apply.
Major depression vs bipolar disorder
Drugs rated for both conditions, sorted by the gap. The number on the right is the bipolar rating minus the major depression rating.
All drugs
Follows the filters above and includes drugs with no reviews yet. Tap a column to sort.
About this data
Source. Drugs.com lists of drugs used to treat Depression, Major Depressive Disorder and Bipolar Disorder, copied on Oct 22 and 23, 2026. Ratings are patients' own scores out of 10 for that drug when used for that condition. Drugs.com's bipolar category covers bipolar disorder as a whole, not only its depressive episodes.
Brand names. On Drugs.com, a generic drug's listing already includes the reviews of its brand-name versions (sertraline's count includes Zoloft's), so each drug's rating and review count come from its generic listing. Adding the brand listings on top would count those reviews twice.
Views. Major depression combines Drugs.com's Depression and Major Depressive Disorder categories. Bipolar disorder is Drugs.com's Bipolar Disorder category, whose reviews are mostly about antipsychotics and mood stabilizers. Total combines both. Each review is filed under one condition, so combining adds the review counts and averages the ratings weighted by review count. Because Drugs.com rounds ratings to one decimal, a combined rating can differ from an exact recount by about 0.05.
Adjusted rating. A drug with five glowing reviews shouldn't outrank one with a thousand good ones. The adjusted rating treats every drug as if it also had 25 reviews at the average rating for the selected view: (reviews × rating + 25 × view average) ÷ (reviews + 25). A drug with a handful of reviews moves most of the way toward the average; one with hundreds barely moves.
Drug class. Class and group were assigned by Claude, not taken from Drugs.com. Off-label means Drugs.com flags the drug as not approved for that condition; in a combined view, a drug counts as off-label only if it is off-label for every condition included.
Reading the ratings. Reviews are self-selected and lean toward strong reactions, so treat ratings as patient sentiment rather than a measure of how well a drug works. Controlled substances such as opioids, benzodiazepines and stimulants rate high here, which may reflect how they feel to take as much as how they treat the condition.